Humors and imbalances ...

... From Melancholia to Prozac by Clark Lawlor - review | Books | The Guardian. (Hat tip, Dave Lull.)

Many years ago I edited some papers for the Carrier Foundation Clinic.On paper in particular has stayed in my memory. It was a historical study of depression. It seems that in fifth century Athens and also Elizabethan England there appears to have been epidemics of depression. It was so common among the English that people on the continent referred to melancholia as "the Englishman's disease." Luckily, my fundamental shallowness has rendered me more or less immune to the condition.